Drug interactions
Glyburide + Xipamide
Severity: Moderate
Glyburide and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-like diuretics can raise blood glucose and reduce the effect of sulfonylureas. Xipamide may therefore worsen glycemic control.
What this interaction means in plain words
Glyburide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diuretic-induced hypokalemia and impaired insulin secretion and sensitivity oppose glyburide action; the legacy renal clearance explanation is not well supported.
What to do
Monitor blood glucose and potassium after starting xipamide and adjust the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Xipamide?
MediHelp rates the interaction as moderate. Glyburide and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-like diuretics can raise blood glucose and reduce the effect of sulfonylureas. Xipamide may therefore worsen glycemic control.
How serious is the interaction between Glyburide and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and potassium after starting xipamide and adjust the antidiabetic regimen as needed.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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