Drug interactions
Glyburide-metformin + Ibuprofen
Severity: Moderate
Glyburide-metformin and Ibuprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen may modestly potentiate the hypoglycemic effect of glyburide. NSAIDs can also impair renal function, which may increase metformin accumulation.
What this interaction means in plain words
Glyburide-metformin and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Ibuprofen belongs to Musculoskeletal.
Why it happens
Competition for CYP2C9 metabolism and protein binding, plus NSAID-induced renal hemodynamic effects.
What to do
Monitor blood glucose when starting regular ibuprofen and lower the glyburide dose if hypoglycemia occurs. Avoid prolonged NSAID use in patients with reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide-metformin and Ibuprofen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Glyburide-metformin with Ibuprofen?
MediHelp rates the interaction as moderate. Glyburide-metformin and Ibuprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ibuprofen may modestly potentiate the hypoglycemic effect of glyburide. NSAIDs can also impair renal function, which may increase metformin accumulation.
How serious is the interaction between Glyburide-metformin and Ibuprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting regular ibuprofen and lower the glyburide dose if hypoglycemia occurs. Avoid prolonged NSAID use in patients with reduced renal function.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
