Drug interactions
Glyburide-metformin + Imipramine
Severity: Minor
Glyburide-metformin and Imipramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants may enhance glucose-lowering and occasionally cause hypoglycemia or alter glycemic control in patients taking sulfonylureas. The effect is usually modest and variable.
What this interaction means in plain words
Glyburide-metformin and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Imipramine belongs to Central Nervous System.
Why it happens
Proposed additive pharmacodynamic effects on insulin secretion and glucose metabolism; the mechanism is not well established.
What to do
Be aware of altered glucose control when starting or stopping the antidepressant. Check blood glucose if symptoms of hypoglycemia occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Imipramine
- Dronedarone + Imipramine Contraindicated
- Imipramine + Isocarboxazid Contraindicated
- Imipramine + Phenelzine Contraindicated
- Imipramine + Pimozide Contraindicated
- Imipramine + Rasagiline Contraindicated
- Imipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Imipramine?
MediHelp rates the interaction as minor. Glyburide-metformin and Imipramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants may enhance glucose-lowering and occasionally cause hypoglycemia or alter glycemic control in patients taking sulfonylureas. The effect is usually modest and variable.
How serious is the interaction between Glyburide-metformin and Imipramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Be aware of altered glucose control when starting or stopping the antidepressant. Check blood glucose if symptoms of hypoglycemia occur.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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