Drug interactions
Glyburide-metformin + Ivosidenib
Severity: Moderate
Glyburide-metformin and Ivosidenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ivosidenib can induce CYP2C9, which may lower glyburide concentrations and weaken glycemic control. Loss of glucose control may emerge gradually after ivosidenib is started.
What this interaction means in plain words
Glyburide-metformin and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Ivosidenib belongs to Oncology.
Why it happens
Ivosidenib induces CYP2C9, increasing the metabolic clearance of glyburide.
What to do
Monitor blood glucose and HbA1c after starting ivosidenib. Increase the glyburide dose or switch agents if glycemic control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Ivosidenib
- Alfuzosin + Ivosidenib Major
- Amiodarone + Ivosidenib Major
- Amisulpride + Ivosidenib Major
- Amitriptyline + Ivosidenib Major
- Amobarbital + Ivosidenib Major
- Anagrelide + Ivosidenib Major
Frequently asked questions
Can I take Glyburide-metformin with Ivosidenib?
MediHelp rates the interaction as moderate. Glyburide-metformin and Ivosidenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ivosidenib can induce CYP2C9, which may lower glyburide concentrations and weaken glycemic control. Loss of glucose control may emerge gradually after ivosidenib is started.
How serious is the interaction between Glyburide-metformin and Ivosidenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting ivosidenib. Increase the glyburide dose or switch agents if glycemic control worsens.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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