Drug interactions
Glyburide-metformin + Levonorgestrel
Severity: Minor
Glyburide-metformin and Levonorgestrel: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Progestins may slightly impair glucose tolerance and reduce the effect of antidiabetic drugs. With emergency or low-dose levonorgestrel the effect is usually small.
What this interaction means in plain words
Glyburide-metformin and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Levonorgestrel belongs to Endocrine.
Why it happens
Progestins can modestly increase insulin resistance, opposing glucose-lowering therapy.
What to do
No routine change is needed. Check glucose readings if control worsens during prolonged use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Levonorgestrel
Frequently asked questions
Can I take Glyburide-metformin with Levonorgestrel?
MediHelp rates the interaction as minor. Glyburide-metformin and Levonorgestrel have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Progestins may slightly impair glucose tolerance and reduce the effect of antidiabetic drugs. With emergency or low-dose levonorgestrel the effect is usually small.
How serious is the interaction between Glyburide-metformin and Levonorgestrel?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Check glucose readings if control worsens during prolonged use.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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