Drug interactions
Glyburide-metformin + Meloxicam
Severity: Moderate
Glyburide-metformin and Meloxicam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Meloxicam is a CYP2C9 substrate and may slightly enhance sulfonylurea effects, though clinically significant hypoglycemia is uncommon. NSAIDs can also impair renal function and raise metformin exposure.
What this interaction means in plain words
Glyburide-metformin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Meloxicam belongs to Musculoskeletal.
Why it happens
Possible competition at CYP2C9 and protein binding, with NSAID-related renal effects reducing metformin clearance.
What to do
Monitor blood glucose and renal function when meloxicam is used. Adjust the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Meloxicam
- Ketorolac intranasal + Meloxicam Contraindicated
- Ketorolac + Meloxicam Contraindicated
- Aceclofenac + Meloxicam Major
- Acemetacin + Meloxicam Major
- Acetylsalicylic acid + Meloxicam Major
- Alteplase + Meloxicam Major
Frequently asked questions
Can I take Glyburide-metformin with Meloxicam?
MediHelp rates the interaction as moderate. Glyburide-metformin and Meloxicam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Meloxicam is a CYP2C9 substrate and may slightly enhance sulfonylurea effects, though clinically significant hypoglycemia is uncommon. NSAIDs can also impair renal function and raise metformin exposure.
How serious is the interaction between Glyburide-metformin and Meloxicam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when meloxicam is used. Adjust the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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