Drug interactions
Glyburide-metformin + Naproxen
Severity: Moderate
Glyburide-metformin and Naproxen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as naproxen may potentiate the glucose-lowering effect of glyburide, occasionally causing hypoglycemia. Renal effects of NSAIDs can also increase metformin accumulation.
What this interaction means in plain words
Glyburide-metformin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Naproxen belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement of glyburide and NSAID-related reduction in renal metformin clearance.
What to do
Monitor blood glucose and renal function during NSAID use. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Glyburide-metformin with Naproxen?
MediHelp rates the interaction as moderate. Glyburide-metformin and Naproxen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as naproxen may potentiate the glucose-lowering effect of glyburide, occasionally causing hypoglycemia. Renal effects of NSAIDs can also increase metformin accumulation.
How serious is the interaction between Glyburide-metformin and Naproxen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function during NSAID use. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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