Drug interactions
Glyburide-metformin + Nelfinavir
Severity: Moderate
Glyburide-metformin and Nelfinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
HIV protease inhibitors such as nelfinavir can cause insulin resistance and hyperglycemia, which may blunt the glucose-lowering effect of glyburide-metformin. Glycemic control can deteriorate or diabetes may be unmasked during therapy.
What this interaction means in plain words
Glyburide-metformin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Nelfinavir belongs to Anti Virals.
Why it happens
Protease inhibitor-induced insulin resistance and altered glucose metabolism oppose the antidiabetic drugs (pharmacodynamic antagonism).
What to do
Monitor blood glucose and HbA1c more frequently after starting or stopping nelfinavir. Titrate the antidiabetic regimen as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Nelfinavir
- Alfuzosin + Nelfinavir Contraindicated
- Avanafil + Nelfinavir Contraindicated
- Dronedarone + Nelfinavir Contraindicated
- Eletriptan + Nelfinavir Contraindicated
- Ergotamine + Nelfinavir Contraindicated
- Flibanserin + Nelfinavir Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Nelfinavir?
MediHelp rates the interaction as moderate. Glyburide-metformin and Nelfinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. HIV protease inhibitors such as nelfinavir can cause insulin resistance and hyperglycemia, which may blunt the glucose-lowering effect of glyburide-metformin. Glycemic control can deteriorate or diabetes may be unmasked during therapy.
How serious is the interaction between Glyburide-metformin and Nelfinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c more frequently after starting or stopping nelfinavir. Titrate the antidiabetic regimen as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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