Drug interactions
Glyburide-metformin + Niacin
Severity: Moderate
Glyburide-metformin and Niacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Niacin at lipid-lowering doses raises blood glucose and may worsen control in diabetic patients. Dose adjustment of antidiabetic drugs is sometimes needed.
What this interaction means in plain words
Glyburide-metformin and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Niacin belongs to Cardiovascular.
Why it happens
Niacin induces insulin resistance and increases hepatic glucose output, opposing antidiabetic effects.
What to do
Monitor blood glucose and HbA1c after starting or increasing niacin. Increase antidiabetic therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Niacin
- Alogliptin-metformin + Niacin Moderate
- Atorvastatin + Niacin Moderate
- Canagliflozin-metformin + Niacin Moderate
- Cholestyramine + Niacin Moderate
- Colestipol + Niacin Moderate
- Dapagliflozin-metformin + Niacin Moderate
Frequently asked questions
Can I take Glyburide-metformin with Niacin?
MediHelp rates the interaction as moderate. Glyburide-metformin and Niacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Niacin at lipid-lowering doses raises blood glucose and may worsen control in diabetic patients. Dose adjustment of antidiabetic drugs is sometimes needed.
How serious is the interaction between Glyburide-metformin and Niacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and HbA1c after starting or increasing niacin. Increase antidiabetic therapy if control worsens.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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