Drug interactions
Glyburide-metformin + Nifedipine
Severity: Minor
Glyburide-metformin and Nifedipine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nifedipine can modestly impair glucose tolerance in some patients, which may reduce the effectiveness of glyburide-metformin. The effect is usually small and variable, but glycemic control can drift after nifedipine is started.
What this interaction means in plain words
Glyburide-metformin and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Nifedipine belongs to Cardiovascular.
Why it happens
Calcium channel blockade may reduce insulin secretion and insulin sensitivity, causing mild pharmacodynamic antagonism of antidiabetic effect.
What to do
Check blood glucose more often after starting or stopping nifedipine and adjust the antidiabetic dose if control changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide-metformin and Nifedipine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Nifedipine
Frequently asked questions
Can I take Glyburide-metformin with Nifedipine?
MediHelp rates the interaction as minor. Glyburide-metformin and Nifedipine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Nifedipine can modestly impair glucose tolerance in some patients, which may reduce the effectiveness of glyburide-metformin. The effect is usually small and variable, but glycemic control can drift after nifedipine is started.
How serious is the interaction between Glyburide-metformin and Nifedipine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose more often after starting or stopping nifedipine and adjust the antidiabetic dose if control changes.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
