Drug interactions
Glyburide-metformin + Ofloxacin
Severity: Moderate
Glyburide-metformin and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both severe hypoglycemia and hyperglycemia, particularly in diabetic patients taking sulfonylureas such as glyburide. Elderly patients and those with renal impairment are at greater risk.
What this interaction means in plain words
Glyburide-metformin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones alter pancreatic beta-cell insulin release via potassium channel effects, adding to sulfonylurea-induced insulin secretion.
What to do
Monitor blood glucose closely during the antibiotic course and educate the patient on hypoglycemia symptoms; consider a non-quinolone alternative in high-risk patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Glyburide-metformin with Ofloxacin?
MediHelp rates the interaction as moderate. Glyburide-metformin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both severe hypoglycemia and hyperglycemia, particularly in diabetic patients taking sulfonylureas such as glyburide. Elderly patients and those with renal impairment are at greater risk.
How serious is the interaction between Glyburide-metformin and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during the antibiotic course and educate the patient on hypoglycemia symptoms; consider a non-quinolone alternative in high-risk patients.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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