Drug interactions
Glyburide-metformin + Pasireotide
Severity: Major
Glyburide-metformin and Pasireotide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide frequently causes hyperglycemia by suppressing insulin and incretin secretion. This can substantially reduce glycemic control on glyburide-metformin.
What this interaction means in plain words
Glyburide-metformin and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glyburide-metformin belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Somatostatin receptor agonism reduces insulin and incretin secretion, opposing antidiabetic drugs.
What to do
Check glucose before starting pasireotide and monitor frequently; intensify antidiabetic treatment as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glyburide-metformin
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Glyburide-metformin with Pasireotide?
MediHelp rates the interaction as major. Glyburide-metformin and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pasireotide frequently causes hyperglycemia by suppressing insulin and incretin secretion. This can substantially reduce glycemic control on glyburide-metformin.
How serious is the interaction between Glyburide-metformin and Pasireotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check glucose before starting pasireotide and monitor frequently; intensify antidiabetic treatment as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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