Drug interactions
Glyburide-metformin + Prednisolone
Severity: Moderate
Glyburide-metformin and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic prednisolone raises blood glucose and can weaken the effect of glyburide and metformin. Hyperglycemia may be significant with higher doses or longer courses.
What this interaction means in plain words
Glyburide-metformin and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Prednisolone belongs to Endocrine.
Why it happens
Glucocorticoids increase gluconeogenesis and insulin resistance, opposing the antidiabetic drugs.
What to do
Monitor blood glucose more often during steroid therapy and increase antidiabetic doses if needed. Reduce doses as the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Prednisolone?
MediHelp rates the interaction as moderate. Glyburide-metformin and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic prednisolone raises blood glucose and can weaken the effect of glyburide and metformin. Hyperglycemia may be significant with higher doses or longer courses.
How serious is the interaction between Glyburide-metformin and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often during steroid therapy and increase antidiabetic doses if needed. Reduce doses as the steroid is tapered.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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