Drug interactions
Glyburide-metformin + Primidone
Severity: Moderate
Glyburide-metformin and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone, partly converted to phenobarbital, induces hepatic enzymes and may lower glyburide levels. Glycemic control may worsen, and hypoglycemia can occur after discontinuation.
What this interaction means in plain words
Glyburide-metformin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Primidone belongs to Central Nervous System.
Why it happens
Enzyme induction (CYP2C9 and others) increases glyburide metabolism.
What to do
Monitor blood glucose when primidone is started or stopped and adjust the glyburide dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Glyburide-metformin with Primidone?
MediHelp rates the interaction as moderate. Glyburide-metformin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone, partly converted to phenobarbital, induces hepatic enzymes and may lower glyburide levels. Glycemic control may worsen, and hypoglycemia can occur after discontinuation.
How serious is the interaction between Glyburide-metformin and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when primidone is started or stopped and adjust the glyburide dose as needed.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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