Drug interactions
Glyburide-metformin + Promethazine
Severity: Minor
Glyburide-metformin and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine, a phenothiazine, may raise blood glucose and slightly reduce the effect of glyburide-metformin. The effect is usually modest and clinically minor with short-term use.
What this interaction means in plain words
Glyburide-metformin and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Promethazine belongs to Respiratory.
Why it happens
Phenothiazine-related impairment of insulin secretion and glucose tolerance antagonizes antidiabetic action.
What to do
Monitor blood glucose during extended promethazine therapy and adjust antidiabetic doses if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Glyburide-metformin with Promethazine?
MediHelp rates the interaction as minor. Glyburide-metformin and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine, a phenothiazine, may raise blood glucose and slightly reduce the effect of glyburide-metformin. The effect is usually modest and clinically minor with short-term use.
How serious is the interaction between Glyburide-metformin and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during extended promethazine therapy and adjust antidiabetic doses if control worsens.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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