Drug interactions
Glyburide-metformin + Quinine
Severity: Moderate
Glyburide-metformin and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinine can cause hypoglycemia by stimulating insulin secretion, which may add to the effect of glyburide. Metformin and quinine are both cleared partly by cationic renal secretion, so levels of either could rise slightly.
What this interaction means in plain words
Glyburide-metformin and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Quinine belongs to Anti Parasitic.
Why it happens
Quinine stimulates pancreatic insulin release, adding to sulfonylurea effect, with possible competition for renal cationic transport with metformin.
What to do
Monitor blood glucose closely during quinine therapy and educate the patient about hypoglycemia symptoms. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide-metformin and Quinine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide-metformin
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Quinine?
MediHelp rates the interaction as moderate. Glyburide-metformin and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinine can cause hypoglycemia by stimulating insulin secretion, which may add to the effect of glyburide. Metformin and quinine are both cleared partly by cationic renal secretion, so levels of either could rise slightly.
How serious is the interaction between Glyburide-metformin and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely during quinine therapy and educate the patient about hypoglycemia symptoms. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
