Drug interactions
Glyburide-metformin + Rifabutin
Severity: Moderate
Glyburide-metformin and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin can reduce glyburide exposure and weaken its glucose-lowering effect, which may lead to hyperglycemia. The effect is weaker than with rifampin but can still matter.
What this interaction means in plain words
Glyburide-metformin and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induces hepatic metabolic enzymes (CYP2C9 and CYP3A4), increasing glyburide clearance.
What to do
Monitor blood glucose during and after rifabutin therapy and increase the antidiabetic dose if needed. Reassess the dose when rifabutin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Glyburide-metformin with Rifabutin?
MediHelp rates the interaction as moderate. Glyburide-metformin and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin can reduce glyburide exposure and weaken its glucose-lowering effect, which may lead to hyperglycemia. The effect is weaker than with rifampin but can still matter.
How serious is the interaction between Glyburide-metformin and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during and after rifabutin therapy and increase the antidiabetic dose if needed. Reassess the dose when rifabutin is stopped.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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