Drug interactions
Glyburide-metformin + Safinamide
Severity: Minor
Glyburide-metformin and Safinamide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Safinamide may inhibit intestinal BCRP and so increase exposure to BCRP substrates such as glyburide. This could enhance the glucose-lowering effect, although the clinical significance is unclear.
What this interaction means in plain words
Glyburide-metformin and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Safinamide belongs to Central Nervous System.
Why it happens
Inhibition of intestinal BCRP by safinamide and its metabolite may increase glyburide absorption.
What to do
Monitor blood glucose when safinamide is started and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Safinamide
- Amitriptyline + Safinamide Contraindicated
- Amoxapine + Safinamide Contraindicated
- Amphetamine polistirex + Safinamide Contraindicated
- Clomipramine + Safinamide Contraindicated
- Cyclobenzaprine + Safinamide Contraindicated
- Desipramine + Safinamide Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Safinamide?
MediHelp rates the interaction as minor. Glyburide-metformin and Safinamide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Safinamide may inhibit intestinal BCRP and so increase exposure to BCRP substrates such as glyburide. This could enhance the glucose-lowering effect, although the clinical significance is unclear.
How serious is the interaction between Glyburide-metformin and Safinamide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when safinamide is started and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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