Drug interactions
Glyburide-metformin + Trandolapril
Severity: Moderate
Glyburide-metformin and Trandolapril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors can enhance insulin sensitivity and glucose lowering, which may increase hypoglycemia in patients taking a sulfonylurea such as glyburide. Reduced renal function with ACE inhibitors may also raise metformin exposure and the risk of lactic acidosis in susceptible patients.
What this interaction means in plain words
Glyburide-metformin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Trandolapril belongs to Cardiovascular.
Why it happens
Additive glucose-lowering effects through improved insulin sensitivity, plus possible reduction in renal clearance of metformin when renal perfusion falls.
What to do
Monitor blood glucose and renal function when starting or adjusting trandolapril, and reduce the sulfonylurea dose if hypoglycemia occurs. Hold metformin if renal function deteriorates significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Trandolapril
- Aliskiren + Trandolapril Contraindicated
- Protein a column + Trandolapril Contraindicated
- Sacubitril / valsartan + Trandolapril Contraindicated
- Sacubitril-valsartan + Trandolapril Contraindicated
- Aldesleukin + Trandolapril Major
- Amifostine + Trandolapril Major
Frequently asked questions
Can I take Glyburide-metformin with Trandolapril?
MediHelp rates the interaction as moderate. Glyburide-metformin and Trandolapril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors can enhance insulin sensitivity and glucose lowering, which may increase hypoglycemia in patients taking a sulfonylurea such as glyburide. Reduced renal function with ACE inhibitors may also raise metformin exposure and the risk of lactic acidosis in susceptible patients.
How serious is the interaction between Glyburide-metformin and Trandolapril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function when starting or adjusting trandolapril, and reduce the sulfonylurea dose if hypoglycemia occurs. Hold metformin if renal function deteriorates significantly.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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