Drug interactions
Glyburide-metformin + Triamterene
Severity: Minor
Glyburide-metformin and Triamterene: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin and triamterene are both cationic drugs eliminated by renal tubular secretion, so triamterene may raise metformin exposure. The increase is generally modest but may matter in patients with reduced renal function.
What this interaction means in plain words
Glyburide-metformin and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glyburide-metformin belongs to Endocrine; Triamterene belongs to Cardiovascular.
Why it happens
Competition for renal tubular cationic transporters (OCT2/MATE) reduces clearance of metformin.
What to do
Monitor renal function and glycemic control; reduce the metformin dose if renal function declines or gastrointestinal intolerance appears.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide-metformin
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Glyburide-metformin with Triamterene?
MediHelp rates the interaction as minor. Glyburide-metformin and Triamterene have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metformin and triamterene are both cationic drugs eliminated by renal tubular secretion, so triamterene may raise metformin exposure. The increase is generally modest but may matter in patients with reduced renal function.
How serious is the interaction between Glyburide-metformin and Triamterene?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and glycemic control; reduce the metformin dose if renal function declines or gastrointestinal intolerance appears.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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