Drug interactions
Glyburide-metformin + Vandetanib
Severity: Moderate
Glyburide-metformin and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits OCT2 and may raise metformin concentrations by reducing its renal tubular secretion. Higher metformin exposure could increase gastrointestinal effects and, rarely, lactic acidosis.
What this interaction means in plain words
Glyburide-metformin and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide-metformin belongs to Endocrine; Vandetanib belongs to Oncology.
Why it happens
Inhibition of OCT2-mediated renal secretion of metformin by vandetanib.
What to do
Monitor renal function and for signs of metformin toxicity. Consider reducing the metformin dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide-metformin
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Glyburide-metformin with Vandetanib?
MediHelp rates the interaction as moderate. Glyburide-metformin and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib inhibits OCT2 and may raise metformin concentrations by reducing its renal tubular secretion. Higher metformin exposure could increase gastrointestinal effects and, rarely, lactic acidosis.
How serious is the interaction between Glyburide-metformin and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for signs of metformin toxicity. Consider reducing the metformin dose if adverse effects appear.
What other medicines interact with Glyburide-metformin?
MediHelp also lists interactions of Glyburide-metformin with, for example, Bosentan, Cholic acid, Clarithromycin. The full list is on the Glyburide-metformin page.
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