Drug interactions
Glycerol phenylbutyrate + Prednisolone
Severity: Moderate
Glycerol phenylbutyrate and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids promote protein catabolism, which raises the nitrogen load and plasma ammonia. In patients with urea cycle disorders this can reduce the effectiveness of glycerol phenylbutyrate and may precipitate hyperammonemia.
What this interaction means in plain words
Glycerol phenylbutyrate and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycerol phenylbutyrate belongs to Miscellaneous; Prednisolone belongs to Endocrine.
Why it happens
Corticosteroid-induced protein breakdown increases ammonia production, opposing the nitrogen-scavenging effect of glycerol phenylbutyrate.
What to do
Monitor plasma ammonia closely when starting, stopping or changing the steroid dose. Adjust glycerol phenylbutyrate dosing and protein intake as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Major
- Glycerol phenylbutyrate + Sodium valproate Major
- Glycerol phenylbutyrate + Valproic acid Major
- Cyclosporin + Glycerol phenylbutyrate Moderate
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderate
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderate
Frequently asked questions
Can I take Glycerol phenylbutyrate with Prednisolone?
MediHelp rates the interaction as moderate. Glycerol phenylbutyrate and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids promote protein catabolism, which raises the nitrogen load and plasma ammonia. In patients with urea cycle disorders this can reduce the effectiveness of glycerol phenylbutyrate and may precipitate hyperammonemia.
How serious is the interaction between Glycerol phenylbutyrate and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia closely when starting, stopping or changing the steroid dose. Adjust glycerol phenylbutyrate dosing and protein intake as needed.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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