Drug interactions
Glycerol phenylbutyrate + Quinine
Severity: Minor
Glycerol phenylbutyrate and Quinine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glycerol phenylbutyrate is a weak CYP3A4 inducer and may slightly reduce quinine concentrations. This could lower antimalarial efficacy, though the effect is probably small.
What this interaction means in plain words
Glycerol phenylbutyrate and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glycerol phenylbutyrate belongs to Miscellaneous; Quinine belongs to Anti Parasitic.
Why it happens
Weak induction of CYP3A4 increases quinine metabolism.
What to do
Monitor clinical response to quinine when treating malaria. No routine dose adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Other interactions of Glycerol phenylbutyrate
- Dexamethasone + Glycerol phenylbutyrate Major
- Glycerol phenylbutyrate + Sodium valproate Major
- Glycerol phenylbutyrate + Valproic acid Major
- Cyclosporin + Glycerol phenylbutyrate Moderate
- Dexamethasone-neomycin-polymyxin + Glycerol phenylbutyrate Moderate
- Dexamethasone-tobramycin + Glycerol phenylbutyrate Moderate
Frequently asked questions
Can I take Glycerol phenylbutyrate with Quinine?
MediHelp rates the interaction as minor. Glycerol phenylbutyrate and Quinine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Glycerol phenylbutyrate is a weak CYP3A4 inducer and may slightly reduce quinine concentrations. This could lower antimalarial efficacy, though the effect is probably small.
How serious is the interaction between Glycerol phenylbutyrate and Quinine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response to quinine when treating malaria. No routine dose adjustment is needed.
What other medicines interact with Quinine?
MediHelp also lists interactions of Quinine with, for example, Arsenic trioxide, Dofetilide, Dronedarone. The full list is on the Quinine page.
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