Drug interactions
Glycopyrrolate + Meclizine
Severity: Moderate
Glycopyrrolate and Meclizine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs block muscarinic receptors, so combined use can cause additive dry mouth, constipation, urinary retention, blurred vision and tachycardia. Risk is higher in older adults and those with glaucoma or obstructive conditions.
What this interaction means in plain words
Glycopyrrolate and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glycopyrrolate belongs to Respiratory; Meclizine belongs to Respiratory.
Why it happens
Additive antimuscarinic effects.
What to do
Monitor for anticholinergic effects such as urinary retention and constipation. Avoid the combination in patients with narrow-angle glaucoma or obstruction.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Meclizine
Other interactions of Glycopyrrolate
- Glycopyrrolate + Potassium chloride Major
- Amitriptyline + Glycopyrrolate Moderate
- Atropine + Glycopyrrolate Moderate
- Bethanechol + Glycopyrrolate Moderate
- Chlorpromazine + Glycopyrrolate Moderate
- Clomipramine + Glycopyrrolate Moderate
Frequently asked questions
Can I take Glycopyrrolate with Meclizine?
MediHelp rates the interaction as moderate. Glycopyrrolate and Meclizine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs block muscarinic receptors, so combined use can cause additive dry mouth, constipation, urinary retention, blurred vision and tachycardia. Risk is higher in older adults and those with glaucoma or obstructive conditions.
How serious is the interaction between Glycopyrrolate and Meclizine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for anticholinergic effects such as urinary retention and constipation. Avoid the combination in patients with narrow-angle glaucoma or obstruction.
What other medicines interact with Meclizine?
MediHelp also lists interactions of Meclizine with, for example, Belladonna and opium, Benzhydrocodone / acetaminophen, Brexanolone. The full list is on the Meclizine page.
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