Drug interactions
Glycopyrrolate inhaled + Umeclidinium-vilanterol
Severity: Major
Glycopyrrolate inhaled and Umeclidinium-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both umeclidinium and inhaled glycopyrrolate are long-acting muscarinic antagonists, so combining them duplicates therapy. This raises the risk of anticholinergic effects such as dry mouth, urinary retention, constipation, blurred vision and tachycardia, with no added bronchodilator benefit.
What this interaction means in plain words
Glycopyrrolate inhaled and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive pharmacodynamic antagonism of muscarinic receptors from two drugs of the same class.
What to do
Avoid using two long-acting muscarinic antagonists together and keep only one anticholinergic bronchodilator. If anticholinergic effects appear, stop the duplicate agent.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Glycopyrrolate inhaled with Umeclidinium-vilanterol?
MediHelp rates the interaction as major. Glycopyrrolate inhaled and Umeclidinium-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both umeclidinium and inhaled glycopyrrolate are long-acting muscarinic antagonists, so combining them duplicates therapy. This raises the risk of anticholinergic effects such as dry mouth, urinary retention, constipation, blurred vision and tachycardia, with no added bronchodilator benefit.
How serious is the interaction between Glycopyrrolate inhaled and Umeclidinium-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using two long-acting muscarinic antagonists together and keep only one anticholinergic bronchodilator. If anticholinergic effects appear, stop the duplicate agent.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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