Drug interactions
Glycopyrronium tosylate + Thioridazine
Severity: Minor
Glycopyrronium tosylate and Thioridazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Topical glycopyrronium tosylate is applied to the skin for hyperhidrosis and can be absorbed enough to cause systemic anticholinergic effects. With thioridazine, which is strongly anticholinergic, these effects may be additive.
What this interaction means in plain words
Glycopyrronium tosylate and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Additive antimuscarinic effects through pharmacodynamic synergism.
What to do
Monitor for dry mouth, blurred vision, urinary hesitancy and constipation; stop the topical product if significant anticholinergic effects occur.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Thioridazine
- Abiraterone + Thioridazine Contraindicated
- Adagrasib + Thioridazine Contraindicated
- Amiodarone + Thioridazine Contraindicated
- Amisulpride + Thioridazine Contraindicated
- Amitriptyline + Thioridazine Contraindicated
- Amoxapine + Thioridazine Contraindicated
Frequently asked questions
Can I take Glycopyrronium tosylate with Thioridazine?
MediHelp rates the interaction as minor. Glycopyrronium tosylate and Thioridazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Topical glycopyrronium tosylate is applied to the skin for hyperhidrosis and can be absorbed enough to cause systemic anticholinergic effects. With thioridazine, which is strongly anticholinergic, these effects may be additive.
How serious is the interaction between Glycopyrronium tosylate and Thioridazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dry mouth, blurred vision, urinary hesitancy and constipation; stop the topical product if significant anticholinergic effects occur.
What other medicines interact with Thioridazine?
MediHelp also lists interactions of Thioridazine with, for example, Abiraterone, Adagrasib, Amiodarone. The full list is on the Thioridazine page.
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