Drug interactions
Grapefruit + Mifepristone
Severity: Moderate
Grapefruit and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit is a food, not a drug, but it inhibits intestinal CYP3A4 and can raise mifepristone exposure. This may increase dose-related adverse effects such as adrenal insufficiency symptoms, hypokalemia and QT prolongation.
What this interaction means in plain words
Grapefruit and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Grapefruit constituents inhibit intestinal CYP3A4, reducing first-pass metabolism of mifepristone.
What to do
Advise patients to avoid grapefruit and grapefruit juice during mifepristone therapy. Monitor for adverse effects if intake occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Grapefruit with Mifepristone?
MediHelp rates the interaction as moderate. Grapefruit and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Grapefruit is a food, not a drug, but it inhibits intestinal CYP3A4 and can raise mifepristone exposure. This may increase dose-related adverse effects such as adrenal insufficiency symptoms, hypokalemia and QT prolongation.
How serious is the interaction between Grapefruit and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid grapefruit and grapefruit juice during mifepristone therapy. Monitor for adverse effects if intake occurs.
What other medicines interact with Mifepristone?
MediHelp also lists interactions of Mifepristone with, for example, Apixaban, Argatroban, Cisapride. The full list is on the Mifepristone page.
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