Drug interactions
Grapefruit + Regorafenib
Severity: Moderate
Grapefruit and Regorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and may increase regorafenib exposure. Regorafenib labeling advises avoiding it.
What this interaction means in plain words
Grapefruit and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Grapefruit components inhibit intestinal CYP3A4 metabolism.
What to do
Advise patients to avoid grapefruit and grapefruit juice during regorafenib treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Regorafenib
Frequently asked questions
Can I take Grapefruit with Regorafenib?
MediHelp rates the interaction as moderate. Grapefruit and Regorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Grapefruit juice inhibits intestinal CYP3A4 and may increase regorafenib exposure. Regorafenib labeling advises avoiding it.
How serious is the interaction between Grapefruit and Regorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid grapefruit and grapefruit juice during regorafenib treatment.
What other medicines interact with Regorafenib?
MediHelp also lists interactions of Regorafenib with, for example, Apalutamide, Atazanavir, Carbamazepine. The full list is on the Regorafenib page.
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