Drug interactions
Grapefruit + Ticagrelor
Severity: Minor
Grapefruit and Ticagrelor: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and can increase ticagrelor exposure modestly. The effect is usually small but may add to bleeding risk with large intake.
What this interaction means in plain words
Grapefruit and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal CYP3A4 by grapefruit constituents.
What to do
Advise limiting large quantities of grapefruit juice. No dose change is needed with usual intake.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ticagrelor
- Itraconazole + Ticagrelor Contraindicated
- Ketoconazole + Ticagrelor Contraindicated
- Levoketoconazole + Ticagrelor Contraindicated
- Abciximab + Ticagrelor Major
- Abrocitinib + Ticagrelor Major
- Acalabrutinib + Ticagrelor Major
Frequently asked questions
Can I take Grapefruit with Ticagrelor?
MediHelp rates the interaction as minor. Grapefruit and Ticagrelor have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice inhibits intestinal CYP3A4 and can increase ticagrelor exposure modestly. The effect is usually small but may add to bleeding risk with large intake.
How serious is the interaction between Grapefruit and Ticagrelor?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise limiting large quantities of grapefruit juice. No dose change is needed with usual intake.
What other medicines interact with Ticagrelor?
MediHelp also lists interactions of Ticagrelor with, for example, Itraconazole, Ketoconazole, Levoketoconazole. The full list is on the Ticagrelor page.
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