Drug interactions
Grapefruit + Vinblastine
Severity: Minor
Grapefruit and Vinblastine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit inhibits intestinal CYP3A4 and may raise exposure to CYP3A4 substrates. Because vinblastine is given intravenously, the effect is likely small, but hepatic effects are possible with heavy intake.
What this interaction means in plain words
Grapefruit and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Furanocoumarins in grapefruit inhibit CYP3A4, mainly in the gut wall.
What to do
Advise patients to avoid large amounts of grapefruit or its juice during treatment. No dose adjustment is needed otherwise.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Vinblastine
Frequently asked questions
Can I take Grapefruit with Vinblastine?
MediHelp rates the interaction as minor. Grapefruit and Vinblastine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit inhibits intestinal CYP3A4 and may raise exposure to CYP3A4 substrates. Because vinblastine is given intravenously, the effect is likely small, but hepatic effects are possible with heavy intake.
How serious is the interaction between Grapefruit and Vinblastine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid large amounts of grapefruit or its juice during treatment. No dose adjustment is needed otherwise.
What other medicines interact with Vinblastine?
MediHelp also lists interactions of Vinblastine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vinblastine page.
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