Drug interactions
Grapefruit + Ziprasidone
Severity: Minor
Grapefruit and Ziprasidone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Grapefruit juice inhibits intestinal CYP3A4 and could slightly raise ziprasidone levels. Studies with strong CYP3A4 inhibitors show only a small increase in ziprasidone exposure, so the effect is expected to be minor.
What this interaction means in plain words
Grapefruit and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of intestinal CYP3A4 by grapefruit constituents.
What to do
No restriction is typically needed. Advise consistent intake and report increased sedation or palpitations.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Grapefruit with Ziprasidone?
MediHelp rates the interaction as minor. Grapefruit and Ziprasidone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Grapefruit juice inhibits intestinal CYP3A4 and could slightly raise ziprasidone levels. Studies with strong CYP3A4 inhibitors show only a small increase in ziprasidone exposure, so the effect is expected to be minor.
How serious is the interaction between Grapefruit and Ziprasidone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No restriction is typically needed. Advise consistent intake and report increased sedation or palpitations.
What other medicines interact with Ziprasidone?
MediHelp also lists interactions of Ziprasidone with, for example, Amiodarone, Amitriptyline, Arsenic trioxide. The full list is on the Ziprasidone page.
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