Drug interactions
Griseofulvin + Imatinib
Severity: Moderate
Griseofulvin and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may lower imatinib concentrations, potentially reducing efficacy in leukemia or GIST.
What this interaction means in plain words
Griseofulvin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Imatinib belongs to Oncology.
Why it happens
CYP3A4 induction by griseofulvin increases imatinib clearance.
What to do
Monitor hematologic or molecular response and consider an alternative antifungal; increase the imatinib dose if the combination is unavoidable.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Griseofulvin with Imatinib?
MediHelp rates the interaction as moderate. Griseofulvin and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may lower imatinib concentrations, potentially reducing efficacy in leukemia or GIST.
How serious is the interaction between Griseofulvin and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor hematologic or molecular response and consider an alternative antifungal; increase the imatinib dose if the combination is unavoidable.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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