Drug interactions
Griseofulvin + Ketoconazole
Severity: Minor
Griseofulvin and Ketoconazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both are antifungals, so combining them is rarely needed. Griseofulvin may reduce ketoconazole levels, though the clinical effect is uncertain.
What this interaction means in plain words
Griseofulvin and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Ketoconazole belongs to Anti Fungals.
Why it happens
Possible CYP3A4 induction by griseofulvin increases ketoconazole metabolism.
What to do
Avoid unnecessary dual antifungal therapy; if used, monitor clinical response.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Griseofulvin
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Griseofulvin with Ketoconazole?
MediHelp rates the interaction as minor. Griseofulvin and Ketoconazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both are antifungals, so combining them is rarely needed. Griseofulvin may reduce ketoconazole levels, though the clinical effect is uncertain.
How serious is the interaction between Griseofulvin and Ketoconazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unnecessary dual antifungal therapy; if used, monitor clinical response.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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