Drug interactions
Griseofulvin + Metformin-pioglitazone
Severity: Minor
Griseofulvin and Metformin-pioglitazone: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is an enzyme inducer and may modestly lower pioglitazone exposure. Because CYP2C8 is the main pathway, the impact on glucose control is likely small.
What this interaction means in plain words
Griseofulvin and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Metformin-pioglitazone belongs to Endocrine.
Why it happens
Hepatic enzyme induction by griseofulvin may increase pioglitazone metabolism.
What to do
Monitor blood glucose during and after griseofulvin therapy and adjust pioglitazone if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Metformin-pioglitazone
Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Metformin-pioglitazone?
MediHelp rates the interaction as minor. Griseofulvin and Metformin-pioglitazone have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is an enzyme inducer and may modestly lower pioglitazone exposure. Because CYP2C8 is the main pathway, the impact on glucose control is likely small.
How serious is the interaction between Griseofulvin and Metformin-pioglitazone?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during and after griseofulvin therapy and adjust pioglitazone if control worsens.
What other medicines interact with Metformin-pioglitazone?
MediHelp also lists interactions of Metformin-pioglitazone with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Metformin-pioglitazone page.
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