Drug interactions
Griseofulvin + Methadone
Severity: Moderate
Griseofulvin and Methadone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin can induce hepatic enzymes and may lower methadone exposure. This could reduce analgesic effect or precipitate opioid withdrawal symptoms in a patient on stable maintenance therapy.
What this interaction means in plain words
Griseofulvin and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Methadone belongs to Musculoskeletal.
Why it happens
Griseofulvin is a weak inducer of hepatic CYP enzymes, potentially increasing CYP3A4-mediated methadone metabolism.
What to do
Monitor for withdrawal symptoms or reduced analgesia when griseofulvin is started, and increase the methadone dose if needed. Reassess the dose and watch for sedation after griseofulvin is stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methadone
- Alvimopan + Methadone Contraindicated
- Calcium / magnesium / potassium / sodium oxybates + Methadone Contraindicated
- Droperidol + Methadone Contraindicated
- Ibutilide + Methadone Contraindicated
- Isocarboxazid + Methadone Contraindicated
- Lefamulin + Methadone Contraindicated
Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Methadone?
MediHelp rates the interaction as moderate. Griseofulvin and Methadone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin can induce hepatic enzymes and may lower methadone exposure. This could reduce analgesic effect or precipitate opioid withdrawal symptoms in a patient on stable maintenance therapy.
How serious is the interaction between Griseofulvin and Methadone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for withdrawal symptoms or reduced analgesia when griseofulvin is started, and increase the methadone dose if needed. Reassess the dose and watch for sedation after griseofulvin is stopped.
What other medicines interact with Methadone?
MediHelp also lists interactions of Methadone with, for example, Alvimopan, Calcium / magnesium / potassium / sodium oxybates, Droperidol. The full list is on the Methadone page.
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