Drug interactions
Griseofulvin + Nifedipine
Severity: Moderate
Griseofulvin and Nifedipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may reduce nifedipine exposure and weaken blood pressure or angina control.
What this interaction means in plain words
Griseofulvin and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Nifedipine belongs to Cardiovascular.
Why it happens
CYP3A4 induction by griseofulvin increases nifedipine first-pass and systemic metabolism.
What to do
Monitor blood pressure and anginal symptoms and increase the nifedipine dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Nifedipine
Frequently asked questions
Can I take Griseofulvin with Nifedipine?
MediHelp rates the interaction as moderate. Griseofulvin and Nifedipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may reduce nifedipine exposure and weaken blood pressure or angina control.
How serious is the interaction between Griseofulvin and Nifedipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and anginal symptoms and increase the nifedipine dose if needed.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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