Drug interactions
Griseofulvin + Nilotinib
Severity: Major
Griseofulvin and Nilotinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may reduce nilotinib concentrations and risk loss of molecular response in leukemia treatment. Nilotinib exposure is sensitive to CYP3A4 inducers.
What this interaction means in plain words
Griseofulvin and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Griseofulvin belongs to Anti Fungals; Nilotinib belongs to Oncology.
Why it happens
Induction of CYP3A4 increases nilotinib metabolism and lowers systemic exposure.
What to do
Avoid the combination and use a non-inducing antifungal. If it cannot be avoided, monitor disease response closely and consider nilotinib levels where available.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Griseofulvin
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Griseofulvin with Nilotinib?
MediHelp rates the interaction as major. Griseofulvin and Nilotinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin may reduce nilotinib concentrations and risk loss of molecular response in leukemia treatment. Nilotinib exposure is sensitive to CYP3A4 inducers.
How serious is the interaction between Griseofulvin and Nilotinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination and use a non-inducing antifungal. If it cannot be avoided, monitor disease response closely and consider nilotinib levels where available.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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