Drug interactions
Griseofulvin + Primidone
Severity: Moderate
Griseofulvin and Primidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital, which can lower griseofulvin levels and compromise antifungal efficacy. Treatment failure or relapse may occur.
What this interaction means in plain words
Griseofulvin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Primidone belongs to Central Nervous System.
Why it happens
Primidone and its metabolite phenobarbital induce hepatic enzymes and may reduce griseofulvin absorption.
What to do
Monitor response to griseofulvin and consider dose increase or an alternative antifungal; check anticonvulsant control if griseofulvin is changed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Griseofulvin with Primidone?
MediHelp rates the interaction as moderate. Griseofulvin and Primidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital, which can lower griseofulvin levels and compromise antifungal efficacy. Treatment failure or relapse may occur.
How serious is the interaction between Griseofulvin and Primidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to griseofulvin and consider dose increase or an alternative antifungal; check anticonvulsant control if griseofulvin is changed.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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