Drug interactions
Griseofulvin + Quinine
Severity: Moderate
Griseofulvin and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may lower quinine concentrations, which could reduce antimalarial efficacy.
What this interaction means in plain words
Griseofulvin and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Quinine belongs to Anti Parasitic.
Why it happens
CYP3A4 induction by griseofulvin increases quinine metabolism.
What to do
Monitor clinical and parasitological response in malaria, and avoid griseofulvin during treatment if feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Griseofulvin with Quinine?
MediHelp rates the interaction as moderate. Griseofulvin and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Griseofulvin may lower quinine concentrations, which could reduce antimalarial efficacy.
How serious is the interaction between Griseofulvin and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical and parasitological response in malaria, and avoid griseofulvin during treatment if feasible.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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