Drug interactions
Griseofulvin + Ritonavir
Severity: Moderate
Griseofulvin and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is metabolized by CYP3A4 and CYP2D6, so griseofulvin may reduce its concentrations. Lower exposure may weaken viral suppression or the boosting of other protease inhibitors.
What this interaction means in plain words
Griseofulvin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Griseofulvin belongs to Anti Fungals; Ritonavir belongs to Anti Virals.
Why it happens
Griseofulvin induces CYP3A4, increasing ritonavir clearance.
What to do
Monitor HIV viral load and consider drug level monitoring. Limit griseofulvin duration or use an alternative antifungal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Griseofulvin
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Griseofulvin with Ritonavir?
MediHelp rates the interaction as moderate. Griseofulvin and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir is metabolized by CYP3A4 and CYP2D6, so griseofulvin may reduce its concentrations. Lower exposure may weaken viral suppression or the boosting of other protease inhibitors.
How serious is the interaction between Griseofulvin and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load and consider drug level monitoring. Limit griseofulvin duration or use an alternative antifungal.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporin, Desogestrel-ethinyl estradiol, Dienogest / estradiol valerate. The full list is on the Griseofulvin page.
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