Drug interactions
Griseofulvin + Sunitinib
Severity: Major
Griseofulvin and Sunitinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin may lower sunitinib and active metabolite concentrations, reducing efficacy. Strong CYP3A4 inducers markedly reduce sunitinib exposure.
What this interaction means in plain words
Griseofulvin and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Griseofulvin belongs to Anti Fungals; Sunitinib belongs to Oncology.
Why it happens
CYP3A4 induction increases sunitinib metabolism.
What to do
Avoid if possible and select an alternative antifungal. If unavoidable, consider a sunitinib dose increase as per labeling with close monitoring for toxicity.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Griseofulvin
Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Frequently asked questions
Can I take Griseofulvin with Sunitinib?
MediHelp rates the interaction as major. Griseofulvin and Sunitinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Griseofulvin may lower sunitinib and active metabolite concentrations, reducing efficacy. Strong CYP3A4 inducers markedly reduce sunitinib exposure.
How serious is the interaction between Griseofulvin and Sunitinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible and select an alternative antifungal. If unavoidable, consider a sunitinib dose increase as per labeling with close monitoring for toxicity.
What other medicines interact with Griseofulvin?
MediHelp also lists interactions of Griseofulvin with, for example, Cyclosporine, Cyclosporin, Desogestrel-ethinyl estradiol. The full list is on the Griseofulvin page.
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