Drug interactions
Griseofulvin + Tadalafil
Severity: Minor
Griseofulvin and Tadalafil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Griseofulvin is a weak CYP3A4 inducer and might slightly lower tadalafil levels. The clinical impact is probably small and not well documented.
What this interaction means in plain words
Griseofulvin and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Griseofulvin belongs to Anti Fungals; Tadalafil belongs to Genitourinary.
Why it happens
Griseofulvin may weakly induce CYP3A4, increasing tadalafil clearance.
What to do
Monitor response to tadalafil and adjust the dose if efficacy is inadequate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tadalafil
- Amyl nitrite + Tadalafil Contraindicated
- Isosorbide dinitrate + Tadalafil Contraindicated
- Isosorbide mononitrate + Tadalafil Contraindicated
- Nitroglycerin po + Tadalafil Contraindicated
- Nitroglycerin rectal + Tadalafil Contraindicated
- Nitroglycerin sublingual + Tadalafil Contraindicated
Other interactions of Griseofulvin
Frequently asked questions
Can I take Griseofulvin with Tadalafil?
MediHelp rates the interaction as minor. Griseofulvin and Tadalafil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Griseofulvin is a weak CYP3A4 inducer and might slightly lower tadalafil levels. The clinical impact is probably small and not well documented.
How serious is the interaction between Griseofulvin and Tadalafil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor response to tadalafil and adjust the dose if efficacy is inadequate.
What other medicines interact with Tadalafil?
MediHelp also lists interactions of Tadalafil with, for example, Amyl nitrite, Isosorbide dinitrate, Isosorbide mononitrate. The full list is on the Tadalafil page.
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