Drug interactions
Guselkumab + Ofatumumab sc
Severity: Moderate
Guselkumab and Ofatumumab sc: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ofatumumab depletes B cells and guselkumab blocks IL-23 signaling, so together they may increase the risk of infection. Their effects are overlapping, and ofatumumab effects persist after dosing.
What this interaction means in plain words
Guselkumab and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive immunosuppression from B-cell depletion and IL-23 inhibition.
What to do
Monitor for signs of infection and avoid starting combined therapy during active infection. Consider the duration of immune effects when switching between agents.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Frequently asked questions
Can I take Guselkumab with Ofatumumab sc?
MediHelp rates the interaction as moderate. Guselkumab and Ofatumumab sc can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ofatumumab depletes B cells and guselkumab blocks IL-23 signaling, so together they may increase the risk of infection. Their effects are overlapping, and ofatumumab effects persist after dosing.
How serious is the interaction between Guselkumab and Ofatumumab sc?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for signs of infection and avoid starting combined therapy during active infection. Consider the duration of immune effects when switching between agents.
What other medicines interact with Guselkumab?
MediHelp also lists interactions of Guselkumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Guselkumab page.
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