Drug interactions
Guselkumab + Pimozide
Severity: Minor
Guselkumab and Pimozide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation can suppress CYP450 enzymes through cytokines, and biologic therapy that reduces inflammation may restore enzyme activity. For guselkumab, which targets IL-23, such an effect on CYP substrates has not been clearly shown, and pimozide has a narrow therapeutic index.
What this interaction means in plain words
Guselkumab and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Guselkumab belongs to Miscellaneous; Pimozide belongs to Central Nervous System.
Why it happens
Theoretical normalization of cytokine-suppressed CYP450 activity; not established for guselkumab.
What to do
No dose change is routinely needed. Monitor clinical response to pimozide when guselkumab is started or stopped.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Pimozide
- Adagrasib + Pimozide Contraindicated
- Amiodarone + Pimozide Contraindicated
- Amisulpride + Pimozide Contraindicated
- Amitriptyline + Pimozide Contraindicated
- Amoxapine + Pimozide Contraindicated
- Anagrelide + Pimozide Contraindicated
Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Frequently asked questions
Can I take Guselkumab with Pimozide?
MediHelp rates the interaction as minor. Guselkumab and Pimozide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation can suppress CYP450 enzymes through cytokines, and biologic therapy that reduces inflammation may restore enzyme activity. For guselkumab, which targets IL-23, such an effect on CYP substrates has not been clearly shown, and pimozide has a narrow therapeutic index.
How serious is the interaction between Guselkumab and Pimozide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is routinely needed. Monitor clinical response to pimozide when guselkumab is started or stopped.
What other medicines interact with Pimozide?
MediHelp also lists interactions of Pimozide with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Pimozide page.
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