Drug interactions
Guselkumab + Rotavirus oral vaccine live
Severity: Moderate
Guselkumab and Rotavirus oral vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rotavirus vaccine is live attenuated. Infants exposed to guselkumab, for example in utero or via breast milk, might be at theoretical risk of vaccine-strain infection. Data are lacking.
What this interaction means in plain words
Guselkumab and Rotavirus oral vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
IL-23 inhibition may impair immune control of replicating live vaccine virus; theoretical.
What to do
In treated patients, avoid live rotavirus vaccine; for infants with in utero or breast milk exposure, weigh benefit and follow specialist guidance on timing.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Frequently asked questions
Can I take Guselkumab with Rotavirus oral vaccine live?
MediHelp rates the interaction as moderate. Guselkumab and Rotavirus oral vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rotavirus vaccine is live attenuated. Infants exposed to guselkumab, for example in utero or via breast milk, might be at theoretical risk of vaccine-strain infection. Data are lacking.
How serious is the interaction between Guselkumab and Rotavirus oral vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: In treated patients, avoid live rotavirus vaccine; for infants with in utero or breast milk exposure, weigh benefit and follow specialist guidance on timing.
What other medicines interact with Guselkumab?
MediHelp also lists interactions of Guselkumab with, for example, Adenovirus types 4 and 7 live, Bcg vaccine live, Influenza virus vaccine quadrivalent intranasal. The full list is on the Guselkumab page.
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