Drug interactions
Guselkumab + Theophylline
Severity: Minor
Guselkumab and Theophylline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Chronic inflammation suppresses CYP450 enzymes, and an IL-23 inhibitor that controls inflammation may restore enzyme activity. This could lower levels of a narrow-therapeutic-index drug such as theophylline. A clinically significant effect has not been shown.
What this interaction means in plain words
Guselkumab and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Guselkumab belongs to Miscellaneous; Theophylline belongs to Respiratory.
Why it happens
Normalization of cytokine-suppressed CYP450 (including CYP1A2) expression as inflammation resolves.
What to do
Consider checking theophylline concentrations after starting or stopping guselkumab, especially if the patient has active inflammatory disease or unstable asthma control.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Theophylline
- Riociguat + Theophylline Contraindicated
- Adenosine + Theophylline Major
- Apalutamide + Theophylline Major
- Bupropion + Theophylline Major
- Carvedilol + Theophylline Major
- Cimetidine + Theophylline Major
Other interactions of Guselkumab
- Adenovirus types 4 and 7 live + Guselkumab Major
- Bcg vaccine live + Guselkumab Major
- Guselkumab + Influenza virus vaccine quadrivalent intranasal Major
- Guselkumab + Measles mumps and rubella vaccine live Major
- Guselkumab + Measles mumps rubella and varicella vaccine live Major
- Guselkumab + Measles vaccine Major
Frequently asked questions
Can I take Guselkumab with Theophylline?
MediHelp rates the interaction as minor. Guselkumab and Theophylline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Chronic inflammation suppresses CYP450 enzymes, and an IL-23 inhibitor that controls inflammation may restore enzyme activity. This could lower levels of a narrow-therapeutic-index drug such as theophylline. A clinically significant effect has not been shown.
How serious is the interaction between Guselkumab and Theophylline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider checking theophylline concentrations after starting or stopping guselkumab, especially if the patient has active inflammatory disease or unstable asthma control.
What other medicines interact with Theophylline?
MediHelp also lists interactions of Theophylline with, for example, Riociguat, Adenosine, Apalutamide. The full list is on the Theophylline page.
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