Drug interactions
Haemophilus influenzae type b vaccine + Obinutuzumab
Severity: Moderate
Haemophilus influenzae type b vaccine and Obinutuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Anti-CD20 therapy depletes B cells and greatly reduces antibody responses to inactivated vaccines such as Hib. Patients may remain unprotected despite vaccination.
What this interaction means in plain words
Haemophilus influenzae type b vaccine and Obinutuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Obinutuzumab-induced B-cell depletion impairs antibody production after vaccination.
What to do
Vaccinate at least 2 to 4 weeks before starting obinutuzumab when possible. Otherwise delay revaccination until B-cell recovery, typically around 6 months after treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Obinutuzumab
Frequently asked questions
Can I take Haemophilus influenzae type b vaccine with Obinutuzumab?
MediHelp rates the interaction as moderate. Haemophilus influenzae type b vaccine and Obinutuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Anti-CD20 therapy depletes B cells and greatly reduces antibody responses to inactivated vaccines such as Hib. Patients may remain unprotected despite vaccination.
How serious is the interaction between Haemophilus influenzae type b vaccine and Obinutuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 to 4 weeks before starting obinutuzumab when possible. Otherwise delay revaccination until B-cell recovery, typically around 6 months after treatment.
What other medicines interact with Obinutuzumab?
MediHelp also lists interactions of Obinutuzumab with, for example, Measles mumps and rubella vaccine, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel. The full list is on the Obinutuzumab page.
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