Drug interactions
Haemophilus influenzae type b vaccine + Prednisone
Severity: Moderate
Haemophilus influenzae type b vaccine and Prednisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids at immunosuppressive doses can blunt the antibody response to inactivated vaccines. Protection after vaccination may be lower than expected in patients taking prednisone.
What this interaction means in plain words
Haemophilus influenzae type b vaccine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Glucocorticoid-mediated suppression of lymphocyte function reduces the immune response to the vaccine.
What to do
Where possible, vaccinate before starting prednisone or delay until the dose is reduced or stopped. If given during immunosuppressive therapy, consider revaccination once immune competence has recovered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Haemophilus influenzae type b vaccine with Prednisone?
MediHelp rates the interaction as moderate. Haemophilus influenzae type b vaccine and Prednisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids at immunosuppressive doses can blunt the antibody response to inactivated vaccines. Protection after vaccination may be lower than expected in patients taking prednisone.
How serious is the interaction between Haemophilus influenzae type b vaccine and Prednisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible, vaccinate before starting prednisone or delay until the dose is reduced or stopped. If given during immunosuppressive therapy, consider revaccination once immune competence has recovered.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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