Drug interactions
Haemophilus influenzae type b vaccine + Procarbazine
Severity: Moderate
Haemophilus influenzae type b vaccine and Procarbazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine-related immunosuppression may reduce antibody response to the conjugate vaccine, leaving the patient inadequately protected against Hib infection.
What this interaction means in plain words
Haemophilus influenzae type b vaccine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression impairs vaccine immune response.
What to do
Vaccinate at least 2 weeks before chemotherapy when possible. If given during or shortly before therapy, revaccinate at least 3 months after treatment ends once immunity has recovered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Haemophilus influenzae type b vaccine with Procarbazine?
MediHelp rates the interaction as moderate. Haemophilus influenzae type b vaccine and Procarbazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine-related immunosuppression may reduce antibody response to the conjugate vaccine, leaving the patient inadequately protected against Hib infection.
How serious is the interaction between Haemophilus influenzae type b vaccine and Procarbazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before chemotherapy when possible. If given during or shortly before therapy, revaccinate at least 3 months after treatment ends once immunity has recovered.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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