Drug interactions
Haemophilus influenzae type b vaccine + Ustekinumab
Severity: Minor
Haemophilus influenzae type b vaccine and Ustekinumab: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ustekinumab may blunt the antibody response to non-live vaccines, but the effect is generally modest. Hib is a conjugate vaccine and can be given, though protection may be lower.
What this interaction means in plain words
Haemophilus influenzae type b vaccine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
IL-12/23 inhibition may modestly reduce T-cell-dependent vaccine responses.
What to do
Where feasible, give the vaccine before starting ustekinumab or between doses. Do not delay indicated vaccination, and consider checking response or revaccinating in high-risk patients.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Haemophilus influenzae type b vaccine and Ustekinumab, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Ustekinumab
- Bcg vaccine live + Ustekinumab Contraindicated
- Typhoid vaccine live + Ustekinumab Contraindicated
- Adalimumab + Ustekinumab Major
- Adenovirus types 4 and 7 live + Ustekinumab Major
- Alefacept + Ustekinumab Major
- Anakinra + Ustekinumab Major
Frequently asked questions
Can I take Haemophilus influenzae type b vaccine with Ustekinumab?
MediHelp rates the interaction as minor. Haemophilus influenzae type b vaccine and Ustekinumab have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ustekinumab may blunt the antibody response to non-live vaccines, but the effect is generally modest. Hib is a conjugate vaccine and can be given, though protection may be lower.
How serious is the interaction between Haemophilus influenzae type b vaccine and Ustekinumab?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where feasible, give the vaccine before starting ustekinumab or between doses. Do not delay indicated vaccination, and consider checking response or revaccinating in high-risk patients.
What other medicines interact with Ustekinumab?
MediHelp also lists interactions of Ustekinumab with, for example, Bcg vaccine live, Typhoid vaccine live, Adalimumab. The full list is on the Ustekinumab page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
